Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage

Trauma and hemorrhagic shock can lead to acute traumatic coagulopathy (ATC) that is not fully reversed by prehospital resuscitation as simulated with a limited volume of fresh whole blood (FWB) in a rat model. Tranexamic Acid (TXA) is used as an anti-fibrinolytic agent to reduce surgical bleeding if...

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Bibliographic Details
Published in:PLoS One
Main Authors: Wu, Xiaowu, Benov, Avi, Darlington, Daniel N., Keesee, Jeffrey D., Liu, Bin, Cap, Andrew P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776384/
https://ncbi.nlm.nih.gov/pubmed/31581265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223406
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