Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-κB Activity in Triple-Negative Breast Cancer Cells

Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer cell viability and rapid proliferation. Pyruvate kinase muscle (PKM) is a rate-limiting enzyme in the final step of glycolysis. Herein, we report that...

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Publicado no:Mol Cells
Main Authors: Ma, Chaobing, Zu, Xueyin, Liu, Kangdong, Bode, Ann M., Dong, Zigang, Liu, Zhenzhen, Kim, Dong Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Molecular and Cellular Biology 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776161/
https://ncbi.nlm.nih.gov/pubmed/31564074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2019.0038
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