Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis

BACKGROUND: Cancer cells reprogram metabolism for proliferation. Phosphoglycerate kinase 1 (PGK1), as a glycolytic enzyme and newly identified protein kinase, coordinates glycolysis and mitochondrial metabolism. However, the clinical significance of PGK1 expression and function in cancer progression...

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Detalhes bibliográficos
Publicado no:Cancer Commun (Lond)
Main Authors: Shao, Fei, Yang, Xueying, Wang, Wei, Wang, Juhong, Guo, Wei, Feng, Xiaoli, Shi, Susheng, Xue, Qi, Gao, Shugeng, Gao, Yibo, Lu, Zhimin, He, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775656/
https://ncbi.nlm.nih.gov/pubmed/31578148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40880-019-0401-9
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