Highlight article: Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats

Obesity is a risk factor for many chronic diseases, including hypertension, type-2 diabetes, and cancer. Interestingly, concentrations of branched-chain amino acids (BCAAs) in plasma are commonly associated with endothelial dysfunction in humans and animals with obesity. Because L-leucine inhibits n...

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Bibliographic Details
Published in:Exp Biol Med (Maywood)
Main Authors: Tekwe, Carmen D, Yao, Kang, Lei, Jian, Li, Xilong, Gupta, Anand, Luan, Yuanyuan, Meininger, Cynthia J, Bazer, Fuller W, Wu, Guoyao
Format: Artigo
Language:Inglês
Published: SAGE Publications 2019
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775570/
https://ncbi.nlm.nih.gov/pubmed/31357871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370219865229
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