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The Antagonism of Folate Receptor by Dolutegravir: Developmental Toxicity Reduction by Supplemental Folic Acid
OBJECTIVE: Maternal folate (vitamin B9) status is the largest known modifier of neural tube defect (NTD) risk, so we evaluated folate-related mechanisms of action for dolutegravir (DTG) developmental toxicity. DESIGN: Folate receptor (FOLR1) was examined as a target for DTG developmental toxicity us...
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| Publicado no: | AIDS |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6774845/ https://ncbi.nlm.nih.gov/pubmed/31259764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002289 |
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