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Structure of the dynein-2 complex and its assembly with intraflagellar transport trains
Dynein-2 assembles with polymeric intraflagellar transport (IFT) trains to form a transport machinery crucial for cilia biogenesis and signaling. Here we recombinantly expressed the ~1.4 MDa human dynein-2 complex and solved its cryo-EM structure to near-atomic resolution. The two identical copies o...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6774794/ https://ncbi.nlm.nih.gov/pubmed/31451806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0286-y |
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