Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

Neuronal death evoked by DNA damage requires cyclin-dependent kinase 4 (Cdk4) and 6 activity and is accompanied by elevation of cyclin D1-associated kinase activity. Because Cdk4/6 phosphorylates retinoblastoma protein (pRb) family members that then modulate the transcriptional activity of E2F/DP1 c...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Park, David S., Morris, Erick J., Bremner, Rod, Keramaris, Elizabeth, Padmanabhan, Jaya, Rosenbaum, Michele, Shelanski, Michael L., Geller, Herbert M., Greene, Lloyd A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773109/
https://ncbi.nlm.nih.gov/pubmed/10777774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-09-03104.2000
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