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The TASK-1 Two-Pore Domain K(+) Channel Is a Molecular Substrate for Neuronal Effects of Inhalation Anesthetics

Despite widespread use of volatile general anesthetics for well over a century, the mechanisms by which they alter specific CNS functions remain unclear. Here, we present evidence implicating the two-pore domain, pH-sensitive TASK-1 channel as a target for specific, clinically important anesthetic e...

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Pubblicato in:J Neurosci
Autori principali: Sirois, Jay E., Lei, Qiubo, Talley, Edmund M., Lynch, Carl, Bayliss, Douglas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772985/
https://ncbi.nlm.nih.gov/pubmed/10964940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-17-06347.2000
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