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CD45 Opposes β-Amyloid Peptide-Induced Microglial Activation via Inhibition of p44/42 Mitogen-Activated Protein Kinase

Reactive microglia have been suggested to play a role in the Alzheimer's disease (AD) process, and previous studies have shown that expression of CD45, a membrane-bound protein-tyrosine phosphatase (PTP), is elevated in microglia in AD brain compared with controls. To investigate the possible r...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tan, Jun, Town, Terrence, Mori, Takashi, Wu, Yajuan, Saxe, Michael, Crawford, Fiona, Mullan, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772874/
https://ncbi.nlm.nih.gov/pubmed/11027218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-20-07587.2000
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