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Deficiency of Complement Defense Protein CD59 May Contribute to Neurodegeneration in Alzheimer's Disease

Complement defense 59 (CD59) is a cell surface glycophosphoinositol (GPI)-anchored protein that prevents complement membrane attack complex (MAC) assembly. Here, we present evidence from ELISA assays that CD59 protein levels are significantly decreased in the frontal cortex and hippocampus of Alzhei...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Yang, Li-Bang, Li, Rena, Meri, Seppo, Rogers, Joseph, Shen, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772855/
https://ncbi.nlm.nih.gov/pubmed/11027207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-20-07505.2000
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