An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion

Rapid perturbation of protein function permits the ability to define primary molecular responses while avoiding downstream cumulative effects of protein dysregulation. The auxin-inducible degron (AID) system was developed as a tool to achieve rapid and inducible protein degradation in nonplant syste...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Sathyan, Kizhakke Mattada, McKenna, Brian D., Anderson, Warren D., Duarte, Fabiana M., Core, Leighton, Guertin, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Resource/Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771385/
https://ncbi.nlm.nih.gov/pubmed/31467088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328237.119
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