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BACE1 Inhibition Using 2’-OMePS Steric Blocking Antisense Oligonucleotides

Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alz...

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Detalles Bibliográficos
Publicado en:Genes (Basel)
Main Authors: Chakravarthy, Madhuri, Veedu, Rakesh N
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770983/
https://ncbi.nlm.nih.gov/pubmed/31547430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10090705
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