SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress

Uncontrolled accumulation of methylglyoxal (MG) and reactive oxygen species (ROS) occurs in hyperglycemia-induced endothelial dysfunction associated with diabetes. Resveratrol (RSV) protects the endothelium upon high glucose (HG); however, the mechanisms underlying such protective effects are still...

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Bibliographic Details
Published in:Antioxidants (Basel)
Main Authors: Santini, Silvano Junior, Cordone, Valeria, Mijit, Mahmut, Bignotti, Virginio, Aimola, Pierpaolo, Dolo, Vincenza, Falone, Stefano, Amicarelli, Fernanda
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770647/
https://ncbi.nlm.nih.gov/pubmed/31480513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8090346
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