The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

Background: Mounting evidence indicate that reducing the sinoatrial node (SAN) activity may be a useful therapeutic strategy to control of heart failure. Purines, like ATP and its metabolite adenosine, consistently reduce the SAN spontaneous activity leading to negative cardiac chronotropy, with var...

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Udgivet i:Front Pharmacol
Main Authors: Bragança, Bruno, Nogueira-Marques, Sílvia, Ferreirinha, Fátima, Fontes-Sousa, Ana Patrícia, Correia-de-Sá, Paulo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769074/
https://ncbi.nlm.nih.gov/pubmed/31611793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01103
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