Primary myelofibrosis marrow-derived CD14(+)/CD34(-) monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes

To confirm that neoplastic monocyte-derived collagen- and fibronectin-producing fibrocytes induce bone marrow (BM) fibrosis in primary myelofibrosis (PMF), we injected PMF BM-derived fibrocyte-precursor CD14(+)/CD34(-) monocytes into the tail vein of NOD-SCID-γ (NSG) mice. PMF BM-derived CD14(+)/CD3...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Manshouri, Taghi, Verstovsek, Srdan, Harris, David M., Veletic, Ivo, Zhang, Xiaorui, Post, Sean M., Bueso-Ramos, Carlos E., Estrov, Zeev
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768666/
https://ncbi.nlm.nih.gov/pubmed/31569199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222912
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