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Treatment of actinic keratosis through inhibition of cyclooxygenase‐2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5%

Cyclooxygenase‐2 (COX‐2) and its metabolic product prostaglandin E(2) (PGE(2)) are induced in response to growth factors, inflammatory cytokines, tumor promoters, activated oncogenes, and, in the skin, ultraviolet (UV) radiation. Accumulating evidence suggests a role for the COX‐2/PGE(2) pathway in...

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Bibliographic Details
Published in:Dermatol Ther
Main Authors: Thomas, Gareth J., Herranz, Pedro, Cruz, Susana Balta, Parodi, Aurora
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767532/
https://ncbi.nlm.nih.gov/pubmed/30523664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dth.12800
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