Impact of heart rate on cross-bridge cycling kinetics in failing and nonfailing human myocardium

The force-frequency relationship (FFR) is an important regulatory mechanism that increases the force-generating capacity as well as the contraction and relaxation kinetics in human cardiac muscle as the heart rate increases. In human heart failure, the normally positive FFR often becomes flat, or ev...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Chung, Jae-Hoon, Milani-Nejad, Nima, Davis, Jonathan P., Weisleder, Noah, Whitson, Bryan A., Mohler, Peter J., Janssen, Paul M. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766727/
https://ncbi.nlm.nih.gov/pubmed/31347914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00163.2019
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