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Sphingosine-1-phosphate analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction

Sarcopenia, the age-associated loss of skeletal muscle mass and function, is coupled with declines in physical functioning leading to subsequent higher rates of disability, frailty, morbidity, and mortality. Aging and obesity independently contribute to muscle atrophy that is assumed to be a result...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Rivas, Donato A., Rice, Nicholas P., Ezzyat, Yassine, McDonald, Devin J., Cooper, Brittany E., Fielding, Roger A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766615/
https://ncbi.nlm.nih.gov/pubmed/31241988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00455.2018
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