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苦参碱通过抑制PI3K/AKT/mTOR通路促进非小细胞肺癌A549细胞的自噬和凋亡
OBJECTIVE: To investigate the inhibitory effect of matrine on the proliferation of human non-small cell lung cancer (NSCLC) and explore the possible molecular mechanism. METHODS: Cultured human NSCLC A549 cells were treated with 0.4, 0.8, 1.2, 1.6, and 2.0 g/L matrine for 24, 48 or 72 h. CCK-8 assay...
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| Publié dans: | Nan Fang Yi Ke Da Xue Xue Bao |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
南方医科大学学报编辑部
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765564/ https://ncbi.nlm.nih.gov/pubmed/31340906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12122/j.issn.1673-4254.2019.07.02 |
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