Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in irritable bowel syndrome

OBJECTIVE: The intestinal lumen contains several proteases. Our aim was to determine the role of fecal proteases in mediating barrier dysfunction and symptoms in IBS. DESIGN: 39 IBS patients and 25 healthy volunteers completed questionnaires, assessments of in vivo permeability, ex vivo colonic barr...

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Bibliographic Details
Published in:Gut
Main Authors: Edogawa, Shoko, Edwinson, Adam L, Peters, Stephanie A, Chikkamenahalli, Lakshmikanth L., Sundt, Wendy J, Graves, Sara, Gurunathan, Sakteesh V., Breen-Lyles, Margaret K, Johnson, Stephen, Dyer, Roy B, Graham, Rondell P., Chen, Jun, Kashyap, Purna, Farrugia, Gianrico, Grover, Madhusudan
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765451/
https://ncbi.nlm.nih.gov/pubmed/30923071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317416
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