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Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism
HLA class II genes provide the strongest genetic contribution to rheumatoid arthritis (RA). HLA-DRB1 alleles encoding the sequence DERAA are RA-protective. Paradoxically, RA risk is increased in women with DERAA(+) children born prior to onset. We developed a sensitive qPCR assay specific for DERAA,...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765309/ https://ncbi.nlm.nih.gov/pubmed/31501349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904779116 |
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