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Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair

The gap junction protein connexin 43 (Cx43) is a key player in wound healing, and inhibitors of Cx43, which speed epidermal wound healing, are currently in clinical trials. Here, we provide direct in vivo evidence that specific phosphorylation events on Cx43 change the physiological response during...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Lastwika, Kristin J., Dunn, Clarence A., Solan, Joell L., Lampe, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765181/
https://ncbi.nlm.nih.gov/pubmed/31427427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.234633
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