Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis

Developmental defects affecting the heart and aortic arch arteries are a significant phenotype observed in individuals with 22q11 deletion syndrome and are caused by a microdeletion on chromosome 22q11. TBX1, one of the deleted genes, is expressed throughout the pharyngeal arches and is considered a...

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Publicat a:Development
Autors principals: Phillips, Helen M., Stothard, Catherine A., Shaikh Qureshi, Wasay M., Kousa, Anastasia I., Briones-Leon, J. Alberto, Khasawneh, Ramada R., O'Loughlin, Chloe, Sanders, Rachel, Mazzotta, Silvia, Dodds, Rebecca, Seidel, Kerstin, Bates, Timothy, Nakatomi, Mitsushiro, Cockell, Simon J., Schneider, Jürgen E., Mohun, Timothy J., Maehr, René, Kist, Ralf, Peters, Heiko, Bamforth, Simon D.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765178/
https://ncbi.nlm.nih.gov/pubmed/31444215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.177618
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