Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA

Extrachromosomal circular DNA (eccDNA) is both a driver of eukaryotic genome instability and a product of programmed genome rearrangements, but its extent had not been surveyed in Oxytricha, a ciliate with elaborate DNA elimination and translocation during development. Here, we captured rearrangemen...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Yerlici, V Talya, Lu, Michael W, Hoge, Carla R, Miller, Richard V, Neme, Rafik, Khurana, Jaspreet S, Bracht, John R, Landweber, Laura F
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765146/
https://ncbi.nlm.nih.gov/pubmed/31504770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz725
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