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Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook

The flagellar hook protein FlgE from spirochaete bacteria self-catalyzes the formation of an unusual inter-subunit lysinoalanine (Lal) crosslink that is critical for cell motility. Unlike other known examples of Lal biosynthesis, conserved cysteine and lysine residues in FlgE spontaneously react to...

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Détails bibliographiques
Publié dans:Nat Chem Biol
Auteurs principaux: Lynch, Michael J., Miller, Michael, James, Milinda, Zhang, Sheng, Zhang, Kai, Li, Chunhao, Charon, Nyles W., Crane, Brian R.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764852/
https://ncbi.nlm.nih.gov/pubmed/31406373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0341-3
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