Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

BACKGROUND: Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potential to identify a broad range of pathogens in a single test. METHODS: In a 1-year, multicenter, prospective study, we investigated the usefulness of metagenomic NGS of CSF for the diagnosis of infecti...

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Udgivet i:N Engl J Med
Main Authors: Wilson, M.R., Sample, H.A., Zorn, K.C., Arevalo, S., Yu, G., Neuhaus, J., Federman, S., Stryke, D., Briggs, B., Langelier, C., Berger, A., Douglas, V., Josephson, S.A., Chow, F.C., Fulton, B.D., DeRisi, J.L., Gelfand, J.M., Naccache, S.N., Bender, J., Dien Bard, J., Murkey, J., Carlson, M., Vespa, P.M., Vijayan, T., Allyn, P.R., Campeau, S., Humphries, R.M., Klausner, J.D., Ganzon, C.D., Memar, F., Ocampo, N.A., Zimmermann, L.L., Cohen, S.H., Polage, C.R., DeBiasi, R.L., Haller, B., Dallas, R., Maron, G., Hayden, R., Messacar, K., Dominguez, S.R., Miller, S., Chiu, C.Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764751/
https://ncbi.nlm.nih.gov/pubmed/31189036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1803396
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