HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11

To escape CD8+ T-cell immunity, human cytomegalovirus (HCMV) US11 redirects MHC-I for rapid ER-associated proteolytic degradation (ERAD). In humans, classical MHC-I molecules are encoded by the highly polymorphic HLA-A, -B and -C gene loci. While HLA-C resists US11 degradation, the specificity for H...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zimmermann, Cosima, Kowalewski, Daniel, Bauersfeld, Liane, Hildenbrand, Andreas, Gerke, Carolin, Schwarzmüller, Magdalena, Le-Trilling, Vu Thuy Khanh, Stevanovic, Stefan, Hengel, Hartmut, Momburg, Frank, Halenius, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764698/
https://ncbi.nlm.nih.gov/pubmed/31527904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008040
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