HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11

To escape CD8+ T-cell immunity, human cytomegalovirus (HCMV) US11 redirects MHC-I for rapid ER-associated proteolytic degradation (ERAD). In humans, classical MHC-I molecules are encoded by the highly polymorphic HLA-A, -B and -C gene loci. While HLA-C resists US11 degradation, the specificity for H...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS Pathog
Hlavní autoři: Zimmermann, Cosima, Kowalewski, Daniel, Bauersfeld, Liane, Hildenbrand, Andreas, Gerke, Carolin, Schwarzmüller, Magdalena, Le-Trilling, Vu Thuy Khanh, Stevanovic, Stefan, Hengel, Hartmut, Momburg, Frank, Halenius, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764698/
https://ncbi.nlm.nih.gov/pubmed/31527904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008040
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky