Rational Design of Fluorogenic and Spontaneously Blinking Labels for Super-Resolution Imaging

[Image: see text] Rhodamine dyes exist in equilibrium between a fluorescent zwitterion and a nonfluorescent lactone. Tuning this equilibrium toward the nonfluorescent lactone form can improve cell-permeability and allow creation of “fluorogenic” compounds—ligands that shift to the fluorescent zwitte...

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Pubblicato in:ACS Cent Sci
Autori principali: Zheng, Qinsi, Ayala, Anthony X., Chung, Inhee, Weigel, Aubrey V., Ranjan, Anand, Falco, Natalie, Grimm, Jonathan B., Tkachuk, Ariana N., Wu, Carl, Lippincott-Schwartz, Jennifer, Singer, Robert H., Lavis, Luke D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764213/
https://ncbi.nlm.nih.gov/pubmed/31572787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00676
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