Characterization of the Functional Heterologous Desensitization of Hypothalamic 5-HT(1A) Receptors after 5-HT(2A)Receptor Activation

Desensitization of 5-HT(1A) receptors could be involved in the long-term therapeutic effect of anxiolytic and antidepressant drugs. Pretreatment of rats with the 5-HT(2A/2C) agonist DOI induces an attenuation of hypothalamic 5-HT(1A)receptor–G(z)-protein signaling, measured as the ACTH and oxytocin...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhang, Yahong, D'Souza, Deborah, Raap, Daní K., Garcia, Francisca, Battaglia, George, Muma, Nancy A., Van de Kar, Louis D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763854/
https://ncbi.nlm.nih.gov/pubmed/11588165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-20-07919.2001
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