Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease

The rate of disease progression in autosomal-dominant polycystic kidney disease (ADPKD) has high intrafamilial variability, suggesting that environmental factors may play a role. We hypothesized that a prevalent form of renal insult may accelerate cystic progression and investigated tubular crystal...

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Pubblicato in:J Clin Invest
Autori principali: Torres, Jacob A., Rezaei, Mina, Broderick, Caroline, Lin, Louis, Wang, Xiaofang, Hoppe, Bernd, Cowley, Benjamin D., Savica, Vincenzo, Torres, Vicente E., Khan, Saeed, Holmes, Ross P., Mrug, Michal, Weimbs, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763267/
https://ncbi.nlm.nih.gov/pubmed/31361604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128503
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