Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy

Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently in hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced activity. The impact of decreased TET activity in solid tumors is not known. Here we show that TET2 mediates the IFN-γ/JAK/ST...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xu, Yan-ping, Lv, Lei, Liu, Ying, Smith, Matthew D., Li, Wen-Cai, Tan, Xian-ming, Cheng, Meng, Li, Zhijun, Bovino, Michael, Aubé, Jeffrey, Xiong, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763236/
https://ncbi.nlm.nih.gov/pubmed/31310587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129317
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