Lysophosphatidic acid–induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4

Lysophosphatidic acid (LPA) is a potent lipid mediator with various biological functions mediated through six G protein–coupled receptors (GPCRs), LPA1–LPA6. Previous studies have demonstrated that LPA–Gα12/Gα13 signaling plays an important role in embryonic vascular development. However, the respon...

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Vydáno v:J Clin Invest
Hlavní autoři: Yasuda, Daisuke, Kobayashi, Daiki, Akahoshi, Noriyuki, Ohto-Nakanishi, Takayo, Yoshioka, Kazuaki, Takuwa, Yoh, Mizuno, Seiya, Takahashi, Satoru, Ishii, Satoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763231/
https://ncbi.nlm.nih.gov/pubmed/31335323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121955
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