Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

We examined the in vivo effects of the hallucinogen 4-iodo-2,5-dimethoxyamphetamine (DOI). DOI suppressed the firing rate of 7 of 12 dorsal raphe (DR) serotonergic (5-HT) neurons and partially inhibited the rest (ED(50) = 20 μg/kg, i.v.), an effect reversed by M100907 (5-HT(2A) antagonist) and picro...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Martín-Ruiz, Raúl, Puig, M. Victoria, Celada, Pau, Shapiro, David A., Roth, Bryan L., Mengod, Guadalupe, Artigas, Francesc
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2001
Konular:
ARTICLE
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763049/
https://ncbi.nlm.nih.gov/pubmed/11739593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-24-09856.2001
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