Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT(1A) receptor partial agonism and α(1)-adrenoceptor antagonism

Trazodone is an antidepressant drug with considerable affinity for 5-HT(1A) receptors and α(1)-adrenoceptors for which the drug is competitive agonist and antagonist, respectively. In this study, we used cell-attached or whole-cell patch-clamp recordings to characterize the effects of trazodone at s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Montalbano, Alberto, Mlinar, Boris, Bonfiglio, Francesco, Polenzani, Lorenzo, Magnani, Maurizio, Corradetti, Renato
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763016/
https://ncbi.nlm.nih.gov/pubmed/31557210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222855
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