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Volume-Activated Chloride Currents Contribute to the Resting Conductance and Invasive Migration of Human Glioma Cells

We used an in vitro model for glioma cell invasion (transwell migration assay) and patch-clamp techniques to investigate the role of volume-activated Cl(−) currents (I(Cl,Vol)) in glioma cell invasion. Hypotonic solutions (≈230 mOsm) activated outwardly rectifying currents that reversed near the equ...

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Pubblicato in:J Neurosci
Autori principali: Ransom, Christopher B., O'Neal, Jeffrey T., Sontheimer, Harald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762888/
https://ncbi.nlm.nih.gov/pubmed/11567057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-19-07674.2001
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