Sodium Channel mRNAs at the Neuromuscular Junction: Distinct Patterns of Accumulation and Effects of Muscle Activity

Voltage-gated sodium channels (VGSCs) are highly concentrated at the neuromuscular junction (NMJ) in mammalian skeletal muscle. Here we test the hypothesis that local upregulation of mRNA contributes to this accumulation. We designed radiolabeled antisense RNA probes, specific for the “adult” Na(V)1...

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Pubblicato in:J Neurosci
Autori principali: Awad, Suad S., Lightowlers, Robert N., Young, Carol, Chrzanowska-Lightowlers, Zofia M. A., Lømo, Terje, Slater, Clarke R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762790/
https://ncbi.nlm.nih.gov/pubmed/11606634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-21-08456.2001
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