PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

The PICK1 protein interacts in neurons with the AMPA-type glutamate receptor subunit 2 (GluR2) and with several other membrane receptors via its single PDZ domain. We show that PICK1 also binds in neurons and in heterologous cells to protein kinase Cα (PKCα) and that the interaction is highly depend...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Perez, Jose L., Khatri, Latika, Chang, Craig, Srivastava, Sapna, Osten, Pavel, Ziff, Edward B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2001
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ARTICLE
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762658/
https://ncbi.nlm.nih.gov/pubmed/11466413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-15-05417.2001
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