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Generation of Aggregated β-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits

We injected a combination of the β-amyloids (Aβs) Aβ40 and Aβ43 to “seed” formation of amyloid deposits in the dorsal dentate gyrus of rats in vivo, on the basis of a theory of Jarrett and Landsbury (1993). Rats were tested on several different learning tasks, and synaptic transmission and plasticit...

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Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Stéphan, Aline, Laroche, Serge, Davis, Sabrina
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762634/
https://ncbi.nlm.nih.gov/pubmed/11466442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-15-05703.2001
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