Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever

Fever is triggered by an elevation of prostaglandin E(2)(PGE(2)) in the brain. However, the mechanism of its elevation remains unanswered. We herein cloned the rat glutathione-dependent microsomal prostaglandin E synthase (mPGES), the terminal enzyme for PGE(2) biosynthesis, and examined its inducti...

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Publicat a:J Neurosci
Autors principals: Yamagata, Kanato, Matsumura, Kiyoshi, Inoue, Wataru, Shiraki, Takuma, Suzuki, Kyoko, Yasuda, Shin, Sugiura, Hiroko, Cao, Chunyu, Watanabe, Yasuyoshi, Kobayashi, Shigeo
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2001
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ARTICLE
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762538/
https://ncbi.nlm.nih.gov/pubmed/11306620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-08-02669.2001
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