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Multiple Distinct Signal Pathways, Including an Autocrine Neurotrophic Mechanism, Contribute to the Survival-Promoting Effect of Depolarization on Spiral Ganglion Neurons In Vitro

We have shown previously that BDNF, neurotrophin-3 (NT-3), chlorphenylthio-cAMP (cpt-cAMP) (a permeant cAMP analog), and membrane depolarization promote spiral ganglion neuron (SGN) survival in vitro in an additive manner, depolarization having the greatest efficacy. Expression of both BDNF and of N...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Hansen, Marlan R., Zha, Xiang-Ming, Bok, Jinwoong, Green, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762385/
https://ncbi.nlm.nih.gov/pubmed/11264301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-07-02256.2001
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