Dissipation of Potassium and Proton Gradients Inhibits Mitochondrial Hyperpolarization and Cytochrome c Release during Neural Apoptosis

Exposure of rat hippocampal neurons or human D283 medulloblastoma cells to the apoptosis-inducing kinase inhibitor staurosporine induced rapid cytochrome c release from mitochondria and activation of the executioner caspase-3. Measurements of cellular tetramethylrhodamine ethyl ester fluorescence an...

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Publicado en:J Neurosci
Autores principales: Poppe, Monika, Reimertz, Claus, Düßmann, Heiko, Krohn, Aaron J., Luetjens, C. Marc, Böckelmann, Doris, Nieminen, Anna-Liisa, Kögel, Donat, Prehn, Jochen H. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2001
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ARTICLE
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762374/
https://ncbi.nlm.nih.gov/pubmed/11426445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-13-04551.2001
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