Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults

BACKGROUND: Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)‐ε4 is a genetic susceptibility risk factor for Alzheimer's disease that also moderates vascular damage. Thi...

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發表在:J Am Heart Assoc
Main Authors: Bown, Corey W., Liu, Dandan, Osborn, Katie E., Gupta, Deepak K., Mendes, Lisa A., Pechman, Kimberly R., Hohman, Timothy J., Wang, Thomas J., Gifford, Katherine A., Jefferson, Angela L.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761646/
https://ncbi.nlm.nih.gov/pubmed/31364446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.011146
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