Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms

During chronic biofilm infections, Pseudomonas aeruginosa bacteria are exposed to increased oxidative stress as a result of the inflammatory response. As reactive oxygen species (ROS) are mutagenic, the evolution of resistance to ciprofloxacin (CIP) in biofilms under oxidative stress conditions was...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Ahmed, Marwa N., Porse, Andreas, Abdelsamad, Ahmed, Sommer, Morten, Høiby, Niels, Ciofu, Oana
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761533/
https://ncbi.nlm.nih.gov/pubmed/31307984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00766-19
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