Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

Micheliolide (MCL), derived from parthenolide (PTL), is known for its antioxidant and anti-inflammatory effects and has multiple roles in inflammatory diseases and tumours. To investigate its effect on renal disease, we intragastrically administrated DMAMCL, a dimethylamino Michael adduct of MCL for...

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Udgivet i:Lab Invest
Main Authors: Peng, Fenfen, Li, Hongyu, Li, Shuting, Wang, Yuxian, Liu, Wenting, Gong, Wangqiu, Yin, Bohui, Chen, Sijia, Zhang, Ying, Luo, Congwei, Zhou, Weidong, Chen, Yihua, Li, Peilin, Huang, Qianyin, Xu, Zhaozhong, Long, Haibo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760645/
https://ncbi.nlm.nih.gov/pubmed/30976056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-019-0245-6
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