Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA/IVB human papillomavirus-associated oropharyngeal squamous cell cancer

BACKGROUND: The human papillomavirus (HPV) E6 oncoprotein enhances the oncogenic potential of ErbB proteins in HPV-related malignancies. This phase I study evaluates the addition of afatinib, an ErbB family inhibitor, and ribavirin to paclitaxel and carboplatin induction chemotherapy in HPV-associat...

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Publicado en:Head Neck
Main Authors: Dunn, Lara A., Fury, Matthew G., Sherman, Eric J., Ho, Alan A., Katabi, Nora, Haque, Sofia S., Pfister, David G.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760238/
https://ncbi.nlm.nih.gov/pubmed/28963790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.24938
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