Immunization With the CSF-470 Vaccine Plus BCG and rhGM-CSF Induced in a Cutaneous Melanoma Patient a TCRβ Repertoire Found at Vaccination Site and Tumor Infiltrating Lymphocytes That Persisted in Blood

The CSF-470 cellular vaccine plus BCG and rhGM-CSF increased distant metastases-free survival in cutaneous melanoma patients stages IIB-IIC-III relative to medium dose IFN-α2b (CASVAC-0401 study). Patient-045 developed a mature vaccination site (VAC-SITE) and a regional cutaneous metastasis (C-MTS),...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Aris, Mariana, Bravo, Alicia Inés, Garcia Alvarez, Heli Magalí, Carri, Ibel, Podaza, Enrique, Blanco, Paula Alejandra, Rotondaro, Cecilia, Bentivegna, Sofia, Nielsen, Morten, Barrio, María Marcela, Mordoh, José
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759869/
https://ncbi.nlm.nih.gov/pubmed/31620131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02213
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