Toll-Like Receptor 3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells

Reproductive tract pathology caused by Chlamydia trachomatis infection is an important global cause of human infertility. To better understand the mechanisms associated with Chlamydia-induced genital tract pathogenesis in humans, we used CRISPR genome editing to disrupt Toll-like receptor 3 (TLR3) f...

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Pubblicato in:Infect Immun
Autori principali: Xu, Jerry Z., Kumar, Ramesh, Gong, Haoli, Liu, Luyao, Ramos-Solis, Nicole, Li, Yujing, Derbigny, Wilbert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759307/
https://ncbi.nlm.nih.gov/pubmed/31383744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00483-19
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