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Enzyme-Instructed Peptide Assemblies Selectively Inhibit Bone Tumors
Alkaline phosphatases (ALP) contribute to immunosuppression in solid tumors, but they, unfortunately, are “undruggable”. Here we report enzyme-instructed assembly of peptides for selectively inhibiting the tumors that overexpress ALP. We developed a precursor with two parts; an amphiphilic, self-ass...
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| Pubblicato in: | Chem |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6758912/ https://ncbi.nlm.nih.gov/pubmed/31552305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chempr.2019.06.020 |
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