Piper sarmentosum Promotes Endothelial Nitric Oxide Production by Reducing Asymmetric Dimethylarginine in Tumor Necrosis Factor-α-Induced Human Umbilical Vein Endothelial Cells

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase (eNOS). ADMA is degraded by dimethylarginine dimethylaminohydrolase (DDAH). Elevated levels of ADMA lead to reduction in nitric oxide (NO) production, which is linked to endothelial dysfunction and ath...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Sundar, Uma Mahgesswary, Ugusman, Azizah, Chua, Hui Kien, Latip, Jalifah, Aminuddin, Amilia
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758593/
https://ncbi.nlm.nih.gov/pubmed/31607906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01033
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