Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors

Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possible relationship with the endogenous opioid system, we explored Δ9-tetrahydrocannabinol (THC) activity in mice l...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ghozland, Sandy, Matthes, Hans W. D., Simonin, Frederic, Filliol, Dominique, Kieffer, Brigitte L., Maldonado, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758535/
https://ncbi.nlm.nih.gov/pubmed/11826143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-03-01146.2002
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